Claude Ambroise

The B73 Maize Genome: Complexity, Diversity, and Dynamics

Patrick S. Schnable, Doreen Ware, Robert S. Fulton et al. · Science · 2009 · 4.1K citations

Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Andrea M. Zuhl, Charles E. Nolan, Michael A. Brodney et al. · Nature Communications · 2016 · 76 citations · Full text

Spirocyclic Sulfamides as β-Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors

Michael A. Brodney, Gabriela Barreiro, Kevin Ogilvie et al. · Journal of Medicinal Chemistry · 2012 · 60 citations · Full text

Drug Target, Peptide Science, Pharmacotherapy +20

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation

Brian T. O’Neill, Elizabeth M. Beck, Christopher R. Butler et al. · Journal of Medicinal Chemistry · 2018 · 41 citations · Full text

Enzyme 1, Inhibitor Lacking Hypopigmentation, Molecular Pharmacology +20

Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators

Thomas A. Chappie, Mario Abdelmessih, Claude Ambroise et al. · ACS Medicinal Chemistry Letters · 2022 · 16 citations · Full text