Andrew R. McKenzie

Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides

S. Stokes, Robert Albert, Ed T. Buurman et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 87 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +6

Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region

Sameer Kawatkar, Thomas A. Keating, N.B. Olivier et al. · Journal of Medicinal Chemistry · 2014 · 63 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Antibacterial FabH Inhibitors with Mode of Action Validated in <i>Haemophilus influenzae</i> by in Vitro Resistance Mutation Mapping

David C. McKinney, Charles J. Eyermann, Rong-Fang Gu et al. · ACS Infectious Diseases · 2016 · 61 citations

Life Sciences, Biochemistry, Medicinal Chemistry +17

Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)

Gabriel Martínez-Botella, John Breen, J. Emmett Duffy et al. · Journal of Medicinal Chemistry · 2012 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

<i>In Vivo</i> Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

Thomas A. Keating, Joseph Newman, N.B. Olivier et al. · ACS Chemical Biology · 2012 · 44 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15