Characterization of seed‐specific benzoyloxyglucosinolate mutations in <i>Arabidopsis thaliana</i>

Daniel J. Kliebenstein, John C. D’Auria, Aditi S. Behere, +7

The Plant Journal

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity

Folkert Reck, Richard A. Alm, Patrick Brassil, +16

Journal of Medicinal Chemistry

Reduced Herg ActivityAntimicrobial ChemotherapyPharmaceutical ChemistryDrug ResistanceMedicinal Chemistry +19

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced p<i>K</i>_a: Antibacterial Agents with an Improved Safety Profile

Folkert Reck, Richard A. Alm, Patrick Brassil, +12

Journal of Medicinal Chemistry

Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region

Sameer Kawatkar, Thomas A. Keating, N.B. Olivier, +9

Journal of Medicinal Chemistry

Antibiotic AdjuvantMolecular BiologyPeptide ScienceAntimicrobial ChemotherapyChemical Biology +21

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors

Jeffrey W. Johannes, Stephanie M. Bates, Carl Beigie, +33

ACS Medicinal Chemistry Letters

Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)

Gabriel Martínez-Botella, John Breen, J. Emmett Duffy, +21

Journal of Medicinal Chemistry

Essential EnzymeMolecular BiologyAntimicrobial ChemotherapyDrug ResistanceAntimicrobial Resistance +16

<i>In Vivo</i> Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

Thomas A. Keating, Joseph Newman, N.B. Olivier, +18

ACS Chemical Biology

Selective Antibacterial CompoundDrug TargetMolecular BiologyAntimicrobial ChemotherapyResistance Mechanisms +16

4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[<i>c</i>][1,2]oxaboroles Are Broad-Spectrum Serine β-Lactamase Inhibitors

David C. McKinney, Fei Zhou, Charles J. Eyermann, +6

ACS Infectious Diseases

Escherichia ColiAntimicrobial ChemotherapyPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +18

Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa

Folkert Reck, David E. Ehmann, Thomas J. Dougherty, +21

Bioorganic & Medicinal Chemistry

Antimicrobial SusceptibilitySafety ProfilePhysicochemical PropertiesMedicineAntibiotic Adjuvant +8