Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

Moran Dvela‐Levitt, Maria Kost‐Alimova, Maheswarareddy Emani, +35

Cell

Protein FunctionAutoimmune DiseaseMedicineNatural SciencesT-regulatory Cell +7

Molecular basis for substrate recruitment to the PRMT5 methylosome

Kathleen M. Mulvaney, Christa Blomquist, Nischal Acharya, +25

Molecular Cell

ChromatinMedicineNatural SciencesEpigenetic ChangeEpigenomics +7

Thiazolopyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B

Manoj Kale, Anandkumar Raichurkar, Shahul Hameed P, +31

Journal of Medicinal Chemistry

Antiparasitic AgentMolecular BiologyAntimicrobial ChemotherapyPharmaceutical ChemistryMtb Mic +19

Antibacterial FabH Inhibitors with Mode of Action Validated in <i>Haemophilus influenzae</i> by in Vitro Resistance Mutation Mapping

David C. McKinney, Charles J. Eyermann, Rong-Fang Gu, +6

ACS Infectious Diseases

Action ValidatedEscherichia ColiAntimicrobial ChemotherapyAntibiotic ResistanceBacterial Pathogens +20

Selective Inhibitors of Bacterial t-RNA-(N¹G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain

Pamela Hill, Ayome Abibi, Robert Albert, +13

Journal of Medicinal Chemistry

Bioorganic ChemistryEngineeringX-ray Cocrystal StructuresMolecular BiologyLid Domain +18

Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction

David C. McKinney, Brian J. McMillan, Matthew J. Ranaghan, +20

Journal of Medicinal Chemistry

Synthesis of Amine- and Thiol-Modified Nucleoside Phosphoramidites for Site-Specific Introduction of Biophysical Probes into RNA

Shengxi Jin, Chandrasekhar V. Miduturu, David C. McKinney, +1

The Journal of Organic Chemistry

Bioorganic ChemistryEngineeringMolecular BiologyCommon Rna NucleotidesChemical Biology +14

Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

Boudewijn L. M. de Jonge, Grant K. Walkup, Sushmita D. Lahiri, +19

Antimicrobial Agents and Chemotherapy

Bioorganic ChemistryAntibiotic AdjuvantValidate PpatAntimicrobial ChemotherapyChemical Biology +20

X-ray Crystal Structures of <i>Escherichia coli</i> RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein

Vadim Molodtsov, Paul Fleming, Charles J. Eyermann, +6

Journal of Medicinal Chemistry

4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[<i>c</i>][1,2]oxaboroles Are Broad-Spectrum Serine β-Lactamase Inhibitors

David C. McKinney, Fei Zhou, Charles J. Eyermann, +6

ACS Infectious Diseases

Escherichia ColiAntimicrobial ChemotherapyPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +18