Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

Gabsang Lee, Eirini P. Papapetrou, Hyesoo Kim, +10

Nature

Mendelian DisorderGenetic DisorderFamilial DysautonomiaInherited Metabolic DiseaseGenetic Epidemiology +4

Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells

Gabsang Lee, Hyesoo Kim, Yechiel Elkabetz, +5

Nature Biotechnology

Induced Pluripotent Stem CellDevelopmental BiologyCell SpecializationMedicineAdult Stem Cell +8

A Poised Chromatin Platform for TGF-β Access to Master Regulators

Qiaoran Xi, Zhanxin Wang, Alexia-Ileana Zaromytidou, +11

Cell

ChromatinTranscriptional RegulationChromatin StructureChromatin RemodelingCell Regulation +12

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

Gabsang Lee, Christina N. Ramirez, Hyesoo Kim, +9

Nature Biotechnology

Rescue Ikbkap ExpressionInduced Pluripotent Stem CellDevelopmental BiologyPluripotent Stem CellsSignaling Pathway +9

Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model

In Young Choi, HoTae Lim, Kenneth Estrellas, +14

Cell Reports

Regenerative MedicineInduced Pluripotent Stem CellDevelopmental BiologySkeletal MuscleDuchenne Muscular Dystrophy +13

miR-371-3 Expression Predicts Neural Differentiation Propensity in Human Pluripotent Stem Cells

Hyesoo Kim, Gabsang Lee, Yosif Ganat, +5

Cell stem cell

Induced Pluripotent Stem CellDevelopmental BiologyMolecular NeuroscienceMedicineStem Cell Research +6

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons

Manoj Kumar, Jesús A. Acevedo-Cintrón, Aanishaa Jhaldiyal, +10

Stem Cell Reports

Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors

In Young Choi, Hotae Lim, Hyeon Jin Cho, +9

eLife

Skeletal Muscle CellsKey RoleEngineeringGeneticsTranscriptional Landscape +17

The length of CpG islands is associated with the distribution of Alu and L1 retroelements

Moo-Il Kang, Mun‐Gan Rhyu, Youngho Kim, +4

Genomics

L1 RetroelementsGeochronologyCpg Islands

Scopoletin Stimulates Melanogenesis <i>via</i> cAMP/PKA Pathway and Partially p38 Activation

Dae‐Sung Kim, Su-Bin Cha, Min-Cheol Park, +4

Biological and Pharmaceutical Bulletin

Molecular RegulationScopoletin Stimulates MelanogenesisCell DeathCell ProliferationCellular Physiology +18