Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

Sangjune Kim, Seung‐Hwan Kwon, Tae‐In Kam, +16

Neuron

Transneuronal PropagationNeurodegenerative DiseasesSynaptic SignalingSynaptic TransmissionDegenerative Pathology +8

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

Gabsang Lee, Eirini P. Papapetrou, Hyesoo Kim, +10

Nature

Mendelian DisorderGenetic DisorderFamilial DysautonomiaInherited Metabolic DiseaseGenetic Epidemiology +4

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

Stuart M. Chambers, Yuchen Qi, Yvonne Mica, +9

Nature Biotechnology

Developmental TimingInduced Pluripotent Stem CellDevelopmental BiologyMedicineStem Cells +8

Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells

Gabsang Lee, Hyesoo Kim, Yechiel Elkabetz, +5

Nature Biotechnology

Induced Pluripotent Stem CellDevelopmental BiologyCell SpecializationMedicineAdult Stem Cell +8

Derivation of neural crest cells from human pluripotent stem cells

Gabsang Lee, Stuart M. Chambers, Mark Tomishima, +1

Nature Protocols

Regenerative MedicineInduced Pluripotent Stem CellDevelopmental BiologyNeural Crest CellsMedicine +8

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

Eirini P. Papapetrou, Gabsang Lee, Nirav Malani, +11

Nature Biotechnology

Induced Pluripotent Stem CellGenomic Safe HarborsGeneticsStem Cell EngineeringHematology +8

Expansion and maintenance of human embryonic stem cell–derived endothelial cells by TGFβ inhibition is Id1 dependent

Daylon James, Hyung-song Nam, Marco Seandel, +11

Nature Biotechnology

Developmental BiologyAngiogenesisEndothelial CellsMedicineId1 Dependent +7

A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs

Jiho Choi, Soohyun Lee, William Mallard, +12

Nature Biotechnology

Cell LineageHuman CellDevelopmental BiologyGeneticsCell Lines +10

Modeling Neural Crest Induction, Melanocyte Specification, and Disease-Related Pigmentation Defects in hESCs and Patient-Specific iPSCs

Yvonne Mica, Gabsang Lee, Stuart M. Chambers, +2

Cell Reports

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

Gabsang Lee, Christina N. Ramirez, Hyesoo Kim, +9

Nature Biotechnology

Rescue Ikbkap ExpressionInduced Pluripotent Stem CellDevelopmental BiologyPluripotent Stem CellsSignaling Pathway +9