Hideho Okada

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

Donald M. O’Rourke, MacLean P. Nasrallah, Arati Desai et al. · Science Translational Medicine · 2017 · 1.7K citations · Full text

Cell Therapy, Antigen Loss, Immunology +16

Actively personalized vaccination trial for newly diagnosed glioblastoma

Norbert Hilf, Sabrina Kuttruff-Coqui, Katrin Frenzel et al. · Nature · 2018 · 897 citations

Vaccination, Neuro-oncology, Vaccination Trial +6

Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment

Sören Müller, Gary Kohanbash, Siyuan Liu et al. · Genome biology · 2017 · 648 citations · Full text

Induction of CD8⁺T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma

Hideho Okada, Paweł Kaliński, Ryo Ueda et al. · Journal of Clinical Oncology · 2010 · 557 citations · Full text

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

Joseph Choe, Payal Watchmaker, Milos Simic et al. · Science Translational Medicine · 2021 · 461 citations · Full text

Chimeric Antigen Receptor, Neuro-oncology, Cell Therapy +15