Mesenchymal stem cells: a double-edged sword in regulating immune responses

Wenzhao Li, Guangwen Ren, Yin Huang, +13

Cell Death and Differentiation

An Osteopontin-Integrin Interaction Plays a Critical Role in Directing Adipogenesis and Osteogenesis by Mesenchymal Stem Cells

Qing Chen, Peishun Shou, Liying Zhang, +13

Stem Cells

SclerostinBone RepairOsteogenesisOsteoporosisOsteopontin-integrin Interaction +22

Interleukin-23 engineering improves CAR T cell function in solid tumors

Xingcong Ma, Peishun Shou, Christof C. Smith, +12

Nature Biotechnology

Cancer ImmunosurveillanceImmunologyAutoimmunityT Cell ImmunityInterleukin-23 Engineering +5

Dual-targeting CAR-T cells with optimal co-stimulation and metabolic fitness enhance antitumor activity and prevent escape in solid tumors

Koichi Hirabayashi, Hongwei Du, Yang Xu, +8

Nature Cancer

Cancer ImmunosurveillanceMedicineImmunologyDual-targeting Car-t CellsOptimal Co-stimulation +6

STING agonist promotes CAR T cell trafficking and persistence in breast cancer

Nuo Xu, Douglas C. Palmer, Alexander C. Robeson, +8

The Journal of Experimental Medicine

Car T CellsBreast OncologyCancer ImmunosurveillanceLimited InfiltrationT-regulatory Cell +11

Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

Qian Yang, Changwen Zheng, Junjie Cao, +11

Cell Death and Differentiation

Local proliferation initiates macrophage accumulation in adipose tissue during obesity

Changbing Zheng, Qiaoling Yang, Jianjun Cao, +6

Cell Death and Disease

THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells

Chuang Sun, Peishun Shou, Hongwei Du, +11

Cancer Cell

Signal TransductionAdaptive Immune SystemImmunologyImmunologic MechanismAntigen Processing +6

CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages

Chunxing Zheng, Qian Yang, Chunliang Xu, +12

Proceedings of the National Academy of Sciences

Obesity-associated InflammationImmunologyImmune RegulationObesity-induced Insulin ResistanceAdipose Tissue Macrophages +22

miR-155 Regulates Immune Modulatory Properties of Mesenchymal Stem Cells by Targeting TAK1-binding Protein 2

Chunliang Xu, Guangwen Ren, Gang Cao, +15

Journal of Biological Chemistry

Nitric OxideImmunosuppressive CapacityT-regulatory CellImmunologyImmune Regulation +22