Angiotensin II–Induced Insulin Resistance Is Associated With Enhanced Insulin Signaling

Takehide Ogihara, Tomoichiro Asano, Katsuyuki Ando, +14

Hypertension

HypertensionInsulin SignalingOxidative StressMetabolic SyndromeMolecular Pharmacology +17

Humoral Regulation of Resistin Expression in 3T3-L1 and Mouse Adipose Cells

Nobuhiro Shojima, Hideyuki Sakoda, Takehide Ogihara, +11

Diabetes

Molecular RegulationAdipokinesMouse Adipose CellsCellular PhysiologyResistin Expression +25

Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis

Clémence Blouet, Hiraku Ono, Gary J. Schwartz

Cell Metabolism

Energy HomeostasisMolecular PhysiologySignal TransductionHypothalamusPhysiology +9

Three Mitogen-Activated Protein Kinases Inhibit Insulin Signaling by Different Mechanisms in 3T3-L1 Adipocytes

Midori Fujishiro, Yukiko Gotoh, Hideki Katagiri, +11

Molecular Endocrinology

AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver

Nanao Horike, Hideyuki Sakoda, Akifumi Kushiyama, +8

Journal of Biological Chemistry

Transcriptional RegulationSignal TransductionSignaling PathwayBiochemistryMolecular Regulation +12

Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats

Hiraku Ono, Alessandro Pocai, Yuhua Wang, +5

Journal of Clinical Investigation

ObesityMetabolic SyndromeNutritionEnergy HomeostasisHypothalamic S6 Kinase +13

Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement

Hiraku Ono, Hitoshi Shimano, Hideki Katagiri, +13

Diabetes

Srebp-1 Knockout MicePathologyFatty Liver DiseaseInsulin SignalingInflammation +17

High-Salt Diet Enhances Insulin Signaling and Induces Insulin Resistance in Dahl Salt-Sensitive Rats

Takehide Ogihara, Tomoichiro Asano, Katsuyuki Ando, +10

Hypertension

NutritionHypertensionInsulin ReceptorInsulin SignalingBlood Pressure +15

Oxidative stress induces insulin resistance by activating the nuclear factor-?B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase

Takehide Ogihara, Tomoichiro Asano, Hideki Katagiri, +13

Diabetologia

Metabolic RemodelingInsulin SignalingNuclear Factor-Oxidative StressMetabolic Syndrome +15

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

Hua Lin, Leona Plum, Hiraku Ono, +6

Diabetes

Insulin ReceptorInsulin SignalingGastrointestinal Peptide HormoneObesityMetabolic Syndrome +20