Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, +251

Nature

Angiotensin II–Induced Insulin Resistance Is Associated With Enhanced Insulin Signaling

Takehide Ogihara, Tomoichiro Asano, Katsuyuki Ando, +14

Hypertension

HypertensionInsulin SignalingOxidative StressMetabolic SyndromeMolecular Pharmacology +17

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Toshimasa Yamauchi, Kazuo Hara, Shiro Maeda, +42

Nature Genetics

Genome-wide Association StudyMetabolic SyndromeGenetic DeterminantDiabetes EpidemiologyGenetics +10

Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population

Momoko Horikoshi, Kazuo Hara, Chikako Ito, +5

Diabetologia

Metabolic SyndromeGenetic DeterminantDiabetes EpidemiologyAutoimmune DiseaseGenetics +11

Humoral Regulation of Resistin Expression in 3T3-L1 and Mouse Adipose Cells

Nobuhiro Shojima, Hideyuki Sakoda, Takehide Ogihara, +11

Diabetes

Molecular RegulationAdipokinesMouse Adipose CellsCellular PhysiologyResistin Expression +25

Three Mitogen-Activated Protein Kinases Inhibit Insulin Signaling by Different Mechanisms in 3T3-L1 Adipocytes

Midori Fujishiro, Yukiko Gotoh, Hideki Katagiri, +11

Molecular Endocrinology

Genome-wide association study identifies three novel loci for type 2 diabetes

Kazuo Hara, Hayato Fujita, Todd A. Johnson, +34

Human Molecular Genetics

GeneticsGenetic EpidemiologyHuman PolymorphismGenomicsGenome-wide Association Studies +22

Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement

Hiraku Ono, Hitoshi Shimano, Hideki Katagiri, +13

Diabetes

Srebp-1 Knockout MicePathologyFatty Liver DiseaseInsulin SignalingInflammation +17

High-Salt Diet Enhances Insulin Signaling and Induces Insulin Resistance in Dahl Salt-Sensitive Rats

Takehide Ogihara, Tomoichiro Asano, Katsuyuki Ando, +10

Hypertension

NutritionHypertensionInsulin ReceptorInsulin SignalingBlood Pressure +15

Oxidative stress induces insulin resistance by activating the nuclear factor-?B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase

Takehide Ogihara, Tomoichiro Asano, Hideki Katagiri, +13

Diabetologia

Metabolic RemodelingInsulin SignalingNuclear Factor-Oxidative StressMetabolic Syndrome +15