Mark R. Harpel

Spectroscopic Studies of Isopenicillin N Synthase

V J Chen, Allen M. Orville, Mark R. Harpel et al. · Journal of Biological Chemistry · 1989 · 133 citations · Full text

Targeting enzyme inhibitors in drug discovery

Robert A. Copeland, Mark R. Harpel, Peter J. Tummino · Expert Opinion on Therapeutic Targets · 2007 · 128 citations

Medicinal Chemistry, Drug Target, Enzymology +13

Gentisate 1,2-dioxygenase from pseudomonas. Purification, characterization, and comparison of the enzymes from Pseudomonas testosteroni and Pseudomonas acidovorans.

Mark R. Harpel, John D. Lipscomb · Journal of Biological Chemistry · 1990 · 116 citations · Full text

Gentisate 1,2-Dioxygenase, Microbial Physiology, Gentisate Analogs +16

Albiglutide, a Long Lasting Glucagon-Like Peptide-1 Analog, Protects the Rat Heart against Ischemia/Reperfusion Injury: Evidence for Improving Cardiac Metabolic Efficiency

Weike Bao, Karpagam Aravindhan, Hasan Alsaid et al. · PLoS ONE · 2011 · 102 citations · Full text

Thiolate ligation of the active site iron(II) of isopenicillin N synthase derives from substrate rather than endogenous cysteine: spectroscopic studies of site-specific Cys .fwdarw. Ser mutated enzymes

Allen M. Orville, Victor J. Chen, Aidas Kriauciunas et al. · Biochemistry · 1992 · 101 citations

Biosynthesis, Thiolate Derives, Biochemistry +12