Makiko Ohtsuji

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi, Moon-Il Kang, Hiromi Okawa et al. · Molecular and Cellular Biology · 2004 · 2.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Structural Basis for Defects of Keap1 Activity Provoked by Its Point Mutations in Lung Cancer

Balasundaram Padmanabhan, Kit I. Tong, Tsutomu Ohta et al. · Molecular Cell · 2006 · 731 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

Tsutomu Ohta, Kumiko Iijima, Mamiko Miyamoto et al. · Cancer Research · 2008 · 628 citations

Medicine, Genetics, Oncology +15

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

Makiko Ohtsuji, Fumiki Katsuoka, Akira Kobayashi et al. · Journal of Biological Chemistry · 2008 · 319 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction

Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka et al. · Genes to Cells · 2011 · 112 citations · Full text

Life Sciences, Neurobiology, Neuroscience +13