Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

Patrick Essletzbichler, Tomasz Konopka, Federica Santoro, +6

Genome Research

GeneticsGenomicsEngineering Megabase DeletionsGenome EngineeringCrispr +15

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

Debora Fumagalli, David Gacquer, Françoise Rothé, +16

Cell Reports

Human and mouse essentiality screens as a resource for disease gene discovery

Pilar Cacheiro, Violeta Muñoz‐Fuentes, Stephen A. Murray, +193

Nature Communications

A reversible gene trap collection empowers haploid genetics in human cells

Tilmann Bürckstümmer, Carina Banning, Philipp Hainzl, +32

Nature Methods

Human CellsGeneticsGenomic MechanismGenetic MechanismMolecular Genetics +4

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

Barbara Mair, Tomasz Konopka, Claudia Kerzendorfer, +6

PLoS Genetics

Breast OncologyEngineeringGeneticsDifferential Drug SensitivityCancer Genes +15

MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

Michal Šmída, Ferran Fece de la Cruz, Claudia Kerzendorfer, +13

Nature Communications

Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells

Josep V. Forment, Mareike Herzog, Julia Coates, +6

Nature Chemical Biology

Developmental BiologyGenome-wide Genetic ScreeningMedicineGeneticsStem Cell Research +4

Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases

Soazig Le Pennec, Tomasz Konopka, David Gacquer, +10

Endocrine Related Cancer

GeneticsPathologyGenomicsTumor BiologyTumor Heterogeneity +14

New 5-Aryl-1<i>H</i>-imidazoles Display in Vitro Antitumor Activity against Apoptosis-Resistant Cancer Models, Including Melanomas, through Mitochondrial Targeting

Véronique Mathieu, Emilie Van Den Berge, Justine Ceusters, +9

Journal of Medicinal Chemistry

Chemoprevention StrategyApoptosisMitochondrial TargetingCell DeathGrowth Inhibition Profiles +20

Genome-wide screening reveals the genetic basis of mammalian embryonic eye development

Justine M. Chee, Louise Lanoue, Dave Clary, +205

BMC Biology