Owen S. Wells

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease

Saskia N. van der Crabben, Marije P. Hennus, Grant A. McGregor et al. · Journal of Clinical Investigation · 2016 · 111 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair

Jessica J. R. Hudson, Shih‐Chieh Chiang, Owen S. Wells et al. · Nature Communications · 2012 · 85 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Specialized interfaces of Smc5/6 control hinge stability and DNA association

Aaron Alt, Hung Quang Dang, Owen S. Wells et al. · Nature Communications · 2017 · 76 citations · Full text

Life Sciences, Biology, Molecular Biology +17

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

Meryem Alagöz, Owen S. Wells, Sherif F. El‐Khamisy · Nucleic Acids Research · 2013 · 65 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +17

Optimizing Transgene Configuration and Protein Fusions to Maximize Dopamine Production for the Gene Therapy of Parkinson's Disease

Hannah J. Stewart, G. Ralph, Liang Fong-Wong et al. · Human Gene Therapy Clinical Development · 2016 · 26 citations

Life Sciences, Biotechnology, Neuroscience +16