Lenalidomide downregulates the cell survival factor, interferon regulatory factor‐4, providing a potential mechanistic link for predicting response

Antonia Lopez‐Girona, Daniel Heintel, Ling‐Hua Zhang, +14

British Journal of Haematology

Potential Mechanistic LinkMixed-phenotype Acute LeukemiaImmunologyImmune RegulationCell Death +22

High expression of cereblon (<i><scp>CRBN</scp></i>) is associated with improved clinical response in patients with multiple myeloma treated with lenalidomide and dexamethasone

Daniel Heintel, Alberto Rocci, Heinz Ludwig, +8

British Journal of Haematology

ImmunodeficienciesImmunologyImmune RegulationPathologyImmunotherapy +23

Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment

Arnold Bolomsky, Karin Schlangen, Wolfgang Schreiner, +2

Journal of Hematology & Oncology

The anti‐mitotic agents PTC‐028 and PTC596 display potent activity in pre‐clinical models of multiple myeloma but challenge the role of <i>BMI‐1</i> as an essential tumour gene

Arnold Bolomsky, Joséphine Muller, Kathrin Stangelberger, +12

British Journal of Haematology

Immunomodulatory drugs thalidomide and lenalidomide affect osteoblast differentiation of human bone marrow stromal cells in vitro

Arnold Bolomsky, Martin Schreder, Tobias Meißner, +4

Experimental Hematology

Bone Marrow FailureBone Morphogenic ProteinMedicineImmunologyOsteoarthritis +7

Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma

Arnold Bolomsky, Dirk Hose, Martin Schreder, +6

Journal of Hematology & Oncology

IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma

Arnold Bolomsky, Michele Ceribelli, Sebastian Scheich, +17

Cancer Cell

Hematological MalignancyPlasma Cell IdentityImmunologyHematologyMultiple Myeloma +4

Maternal embryonic leucine zipper kinase is a novel target for proliferation-associated high-risk myeloma

Arnold Bolomsky, Roy Heusschen, Karin Schlangen, +6

Haematologica

Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas

Sebastian Scheich, Jiji Chen, Jiamin Liu, +26

Cancer Discovery

Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma

Yandan Yang, Arnold Bolomsky, Thomas Oellerich, +23

Nature Communications