Naomi Kamiguchi - Concepedia

Author

Naomi Kamiguchi

Takeda (Japan)

Also Known As

Kamiguchi, Naomi, Naomi Kamiguchi

Publications

255

Citations

H-Index

Concepts

All Affiliations

Takeda (Japan)

About

Naomi Kamiguchi is an author at Takeda (Japan) specializing in medicine, drug discovery, and pharmacology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	5	5	199
2	Natural Sciences	5	5	192
3	Biochemistry	5	5	192
4	Chemical Biology	2	2	71
5	Molecular Biology	1	1	30

Naomi Kamiguchi

Publications

255

Citations

H-Index

Page 1

	Year	Citations
Discovery of 1-[2-Fluoro-4-(1<i>H</i>-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1<i>H</i>-pyrazol-5-yl)pyridazin-4(1<i>H</i>)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor Jun Kunitomo, Masato Yoshikawa, Makoto Fushimi, Journal of Medicinal Chemistry Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry	2014	64
Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders Satoshi Mikami, Shigekazu Sasaki, Yasutomi Asano, Journal of Medicinal Chemistry Drug TargetLead IdentificationNeurochemical BiomarkersCognitive DisordersChemical Biology	2017	41
Discovery of Clinical Candidate <i>N</i>-((1<i>S</i>)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-<i>b</i>]pyrazine-4(1<i>H</i>)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders Satoshi Mikami, Shinji Nakamura, Tomoko Ashizawa, Journal of Medicinal Chemistry Brain-penetrating Phosphodiesterase 2ABrain PenetrationPharmacotherapyCognitive DisordersPharmaceutical Chemistry	2017	37
Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A Akina Harada, Kazunori Suzuki, Shotaro Miura, Nuclear Medicine and Biology Protein FunctionSignal TransductionBiochemistryPhosphodiesterase 10ANatural Sciences	2014	30
Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor Masato Yoshikawa, Haruhi Kamisaki, Jun Kunitomo, Bioorganic & Medicinal Chemistry Medicinal ChemistryBiochemistryNatural SciencesMedicineNovel 2-Oxindole Scaffold	2015	30
Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor Akina Harada, Kazunori Suzuki, Naomi Kamiguchi, PLoS ONE Novel Phosphodiesterase 10APde10a Selective InhibitorNeurochemical BiomarkersPharmacotherapyExperimental Pharmacology	2015	27
A 96-Well Plate Assay for CYP4503A Induction Using Cryopreserved Human Hepatocytes Naomi Kamiguchi, Eiji Aoyama, Teruaki Okuda, Drug Metabolism and Disposition	2010	16
Characterization of the CYP2C8 Active Site by Homology Modeling Toshimasa Tanaka, Naomi Kamiguchi, Teruaki Okuda, Chemical and Pharmaceutical Bulletin	2004	10

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