Concepedia

Naomi Kamiguchi

NK

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Publications

8

Citations

258

H-Index

8

Active since

2004

Affiliations

Takeda (Japan)(Current)

Naomi Kamiguchi is an author at Takeda (Japan) specializing in pharmacology, phosphodiesterase inhibition, and medicinal chemistry.

Publications per year

2004–2017

8

Publications

8

Discovery of 1-[2-Fluoro-4-(1<i>H</i>-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1<i>H</i>-pyrazol-5-yl)pyridazin-4(1<i>H</i>)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor

Jun Kunitomo, Masato Yoshikawa, Makoto Fushimi et al. · Journal of Medicinal Chemistry · 2014 · 65 citations

, , +15

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders

Satoshi Mikami, Shigekazu Sasaki, Yasutomi Asano et al. · Journal of Medicinal Chemistry · 2017 · 41 citations · Full text

, , +16

Discovery of Clinical Candidate <i>N</i>-((1<i>S</i>)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-<i>b</i>]pyrazine-4(1<i>H</i>)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders

Satoshi Mikami, Shinji Nakamura, Tomoko Ashizawa et al. · Journal of Medicinal Chemistry · 2017 · 37 citations · Full text

, , +15

Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor

Masato Yoshikawa, Haruhi Kamisaki, Jun Kunitomo et al. · Bioorganic & Medicinal Chemistry · 2015 · 32 citations · Full text

, , +10

Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A

Akina Harada, Kazunori Suzuki, Shotaro Miura et al. · Nuclear Medicine and Biology · 2014 · 30 citations

, , +9

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