TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms

Kazunori Suzuki, Akina Harada, Hirobumi Suzuki, +2

Neuropsychopharmacology

NeuropsychologyPsychoactive DrugPsychiatryMultiple ParadigmsMedicine +10

In Vivo Pharmacological Characterization of TAK-063, a Potent and Selective Phosphodiesterase 10A Inhibitor with Antipsychotic-Like Activity in Rodents

Kazunori Suzuki, Akina Harada, Eri Shiraishi, +1

Journal of Pharmacology and Experimental Therapeutics

TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington’s Disease

Akina Harada, Kazunori Suzuki, Haruhide Kimura

Journal of Pharmacology and Experimental Therapeutics

Gene and protein analysis of brain derived neurotrophic factor expression in relation to neurological recovery induced by an enriched environment in a rat stroke model

Kenji Hirata, Yuji Kuge, Chiaki Yokota, +9

Neuroscience Letters

NeuroregenerationStroke RehabilitationNeurophysiologyMedicineNeurological Function +13

Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A

Akina Harada, Kazunori Suzuki, Shotaro Miura, +8

Nuclear Medicine and Biology

Protein FunctionSignal TransductionBiochemistryPhosphodiesterase 10ANatural Sciences +7

Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor

Masato Yoshikawa, Haruhi Kamisaki, Jun Kunitomo, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryNatural SciencesMedicineNovel 2-Oxindole Scaffold +5

Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor

Akina Harada, Kazunori Suzuki, Naomi Kamiguchi, +5

PLoS ONE

Novel Phosphodiesterase 10APde10a Selective InhibitorNeurochemical BiomarkersPharmacotherapyExperimental Pharmacology +20

Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents

Akina Harada, Nidhi Kaushal, Kazunori Suzuki, +5

The International Journal of Neuropsychopharmacology

Combined treatment with a selective PDE10A inhibitor TAK‐063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic‐like effects without affecting plasma prolactin levels and cataleptic responses in rodents

Kazunori Suzuki, Akina Harada, Hirobumi Suzuki, +4

Pharmacology Research & Perspectives

Cataleptic ResponsesPsychotropic MedicationSynaptic TransmissionPsychopharmacologyPharmacotherapy +17

Gene expression associated with an enriched environment after transient focal ischemia

Yuji Shono, Chiaki Yokota, Yuji Kuge, +9

Brain Research

Transient Focal IschemiaEnriched EnvironmentVascular BiologyCell BiologyCerebral Blood Flow +6