Michael Popiolek

ADX47273 [S-(4-Fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities

Feng Liu, Steve Grauer, Cody Kelley et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 181 citations

Discovery of the Potent and Selective M1 PAM-Agonist<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-Hydroxytetrahydro-2<i>H</i>-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

Jennifer E. Davoren, Che‐Wah Lee, Michelle R. Garnsey et al. · Journal of Medicinal Chemistry · 2016 · 83 citations · Full text

Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy

Christine P. Diggle, Stacey J. Sukoff Rizzo, Michael Popiolek et al. · The American Journal of Human Genetics · 2016 · 80 citations · Full text

Biallelic Mutations, Neurological Disorder, Striatal Pde10a +10

Design and Synthesis of γ- and δ-Lactam M₁ Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M₁-Selective PAM with Weak Agonist Activity

Jennifer E. Davoren, Michelle R. Garnsey, Betty Pettersen et al. · Journal of Medicinal Chemistry · 2017 · 58 citations · Full text

Effects of <scp>M</scp>1 and <scp>M</scp>4 activation on excitatory synaptic transmission in <scp>CA</scp>1

Catherine A. Thorn, Michael Popiolek, Eda Stark et al. · Hippocampus · 2017 · 52 citations · Full text

Synaptic Transmission, Neurotransmitter, Neurotransmission +18