Heath A. McDonald

TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists

Minghua Cui, Prisca Honoré, Chengmin Zhong et al. · Journal of Neuroscience · 2006 · 310 citations · Full text

Pain Medicine, Trpv1 Antagonists, Immunology +17

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

Jun Chen, Shailen K. Joshi, Stanley DiDomenico et al. · Pain · 2011 · 269 citations · Full text

Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain:  Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties

Arthur Gomtsyan, Erol K. Bayburt, Robert G. Schmidt et al. · Journal of Medicinal Chemistry · 2005 · 163 citations · Full text

Pain Medicine, Immunology, Receptor Antagonists +18

TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics

Prisca Honoré, Joseph P. Mikusa, Bruce R. Bianchi et al. · Pain · 2002 · 110 citations

A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid

Rachid El Kouhen, Carol S. Surowy, Bruce R. Bianchi et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 110 citations