Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase

Kevin Currie, Jeffrey E. Kropf, Tony Lee, +14

Journal of Medicinal Chemistry

Orally Efficacious InhibitorDrug TargetImmunologyPharmacotherapyImmunotherapy +16

Opposite Functions of Histamine H₁ and H₂ Receptors and H₃ Receptor in Substantia Nigra Pars Reticulata

Fu‐Wen Zhou, Jianjun Xu, Yu Zhao, +2

Journal of Neurophysiology

A chemical chaperone improves muscle function in mice with a RyR1 mutation

Chang Seok Lee, Amy D. Hanna, Hui Wang, +16

Nature Communications

Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834

Wendy B. Young, J A Barbosa, Peter Blomgren, +25

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +9

Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases

Peter Blomgren, Jayaraman Chandrasekhar, Julie A. Di Paolo, +19

ACS Medicinal Chemistry Letters

Translational MedicineAutoimmune DiseaseMedicineImmunosuppressive TherapyReceptor Tyrosine Kinase +13

Discovery of highly potent and selective Bruton’s tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

Wendy B. Young, J A Barbosa, Peter Blomgren, +25

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPyridazinone AnalogsBiochemistryMedicineNatural Sciences +10

Calmodulin reverses rundown of L-type Ca²⁺ channels in guinea pig ventricular myocytes

Jianjun Xu, Liying Hao, Asako Kameyama, +1

American Journal of Physiology-Cell Physiology

Calmodulin- and Ca2+-Dependent Facilitation and Inactivation of the CaV1.2 Ca2+ Channels in Guinea-Pig Ventricular Myocytes

Dong‐Yun Han, Etsuko Minobe, Wuyang Wang, +4

Journal of Pharmacological Sciences

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties

Xiaojing Wang, J A Barbosa, Peter Blomgren, +30

ACS Medicinal Chemistry Letters

Mechanisms underlying the modulation of L-type Ca2+ channel by hydrogen peroxide in guinea pig ventricular myocytes

Lei Yang, Jianjun Xu, Etsuko Minobe, +5

The Journal of Physiological Sciences