Gianfranco Lopopolo

Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity

Modesto de Candia, Filomena Fiorella, Gianfranco Lopopolo et al. · Journal of Medicinal Chemistry · 2013 · 38 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa

Gianfranco Lopopolo, Filomena Fiorella, Modesto de Candia et al. · European Journal of Pharmaceutical Sciences · 2010 · 17 citations

Pharmacy, Medicinal Chemistry, Pharmacology +8

How a β-<scp>d</scp>-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study, and Evaluation of Antithrombotic Properties

Benny Danilo Belviso, Rocco Caliandro, Modesto de Candia et al. · Journal of Medicinal Chemistry · 2014 · 15 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults

Francesco Samarelli, Rosa Purgatorio, Gianfranco Lopopolo et al. · European Journal of Medicinal Chemistry · 2024 · 15 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases

Rosa Purgatorio, Nicola Gambacorta, Francesco Samarelli et al. · Molecules · 2022 · 11 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17