Modesto de Candia

Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease

Rosa Purgatorio, Modesto de Candia, Marco Catto et al. · European Journal of Medicinal Chemistry · 2019 · 58 citations · Full text

Medicinal Chemistry, Alzheimer's Disease, Medicine +10

New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity

Modesto de Candia, Giorgia Zaetta, Nunzio Denora et al. · European Journal of Medicinal Chemistry · 2016 · 55 citations · Full text

Nmda-induced Neurotoxicity, Biochemistry, Human Butyrylcholinesterase +9

Fluorinated Benzyloxyphenyl Piperidine-4-carboxamides with Dual Function against Thrombosis: Inhibitors of Factor Xa and Platelet Aggregation

Modesto de Candia, Francesco Liantonio, Andrea Carotti et al. · Journal of Medicinal Chemistry · 2009 · 39 citations · Full text

Combinatorial Chemistry, Pharmaceutical Science, Bioorganic Chemistry +23

Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity

Modesto de Candia, Filomena Fiorella, Gianfranco Lopopolo et al. · Journal of Medicinal Chemistry · 2013 · 38 citations · Full text

Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies

Mariagrazia Rullo, Marco Cipolloni, Marco Catto et al. · Journal of Medicinal Chemistry · 2022 · 36 citations · Full text