The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

Sophie Viaud, Fabiana Saccheri, Grégoire Mignot, +30

Science

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

Rapolas Žilionis, Camilla Engblom, Christina Pfirschke, +15

Immunity

Tumor BiologyOncologyTumor HeterogeneityMedicineSingle Cell Sequencing +10

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

Felix Klug, Hridayesh Prakash, Peter E. Huber, +15

Cancer Cell

Cancer ImmunosurveillanceMedicineT-regulatory CellInos+/m1 PhenotypeImmunology +7

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

Antonella Sistigu, Takahiro Yamazaki, Erika Vacchelli, +48

Nature Medicine

Cancer ImmunosurveillanceMedicineImmunologyTumor ImmunityCancer Cell Biology +6

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

Christina Pfirschke, Camilla Engblom, Steffen Rickelt, +18

Immunity

Tumor ImmunologyCancer ImmunosurveillanceMedicineCheckpoint Blockade TherapyImmunology +3

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

Christopher Garris, Sean P. Arlauckas, Rainer H. Köhler, +20

Immunity

Cancer ImmunosurveillanceImmunologyTumor ImmunityImmune RegulationImmune Surveillance +10

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

Miles A. Miller, Yao‐Rong Zheng, Suresh Gadde, +12

Nature Communications

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF ^high neutrophils

Camilla Engblom, Christina Pfirschke, Rapolas Žilionis, +30

Science

A neutrophil response linked to tumor control in immunotherapy

Jeremy Gungabeesoon, Nicolas A. Gort-Freitas, Máté Kiss, +16

Cell

Tumor ImmunologyCancer ImmunosurveillanceImmunologyTumor ImmunityNeutrophil Response +5

SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions

Ferdinando Pucci, Christopher Garris, Charles Pin‐Kuang Lai, +13

Science