Activation of RalA Is Required for Insulin-Stimulated Glut4 Trafficking to the Plasma Membrane via the Exocyst and the Motor Protein Myo1c

Xiaowei Chen, Dara E. Leto, Shian-Huey Chiang, +2

Developmental Cell

Rala Is RequiredCellular PhysiologyInsulin SignalingInsulin-stimulated Glut4 TraffickingCell Signaling +14

Ribosomal protein RPL26 is the principal target of UFMylation

Christopher P. Walczak, Dara E. Leto, Lichao Zhang, +6

Proceedings of the National Academy of Sciences

Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation

Dara E. Leto, David W. Morgens, Lichao Zhang, +4

Molecular Cell

Off-target EffectGeneticsEr-associated DegradationMolecular GeneticsGene Editing +7

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

Jonathan Mowers, Maeran Uhm, Shannon M. Reilly, +5

eLife

Nfκb PathwayImmunologyRenal InflammationCell DeathCatecholamine Resistance +21

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

Xiaowei Chen, Dara E. Leto, Tingting Xiong, +4

Molecular Biology of the Cell

Molecular RegulationMolecular BiologyCellular PhysiologyInsulin SignalingRal Gap Complex +17

Exocyst function regulated by effector phosphorylation

Xiaowei Chen, Dara E. Leto, Junyu Xiao, +9

Nature Cell Biology

Signal TransductionMedicineCellular Regulatory MechanismFunctional RegulationCellular Biochemistry +5

Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation

Annemieke T. van der Goot, Margaret M.P. Pearce, Dara E. Leto, +2

Molecular Cell

Signal TransductionBiochemistryDecoding GlycanMedicineNatural Sciences +7

Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation

Melissa A. Roberts, Kirandeep K. Deol, Alyssa J. Mathiowetz, +13

Developmental Cell

Lipid Droplet RegulationSystems BiologyFunctional GenomicsOff-target EffectGenetics +13

A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes

Tingting Xiong, Maeran Uhm, Dara E. Leto, +3

Molecular Biology of the Cell

Molecular PhysiologySignal TransductionBiochemistryNatural SciencesPhysiology +13

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

Xiang Wang, Vitaliy V. Bondar, Oliver B. Davis, +13

eLife