Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes

Adrian L. Sanborn, Suhas S.P. Rao, Su-Chen Huang, +14

Proceedings of the National Academy of Sciences

Protein AssemblyGeneticsGenomic MechanismMolecular BiologyEpigenetics +24

Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing

Andreas Gnirke, Alexandre Melnikov, Jared Maguire, +11

Nature Biotechnology

EngineeringGeneticsMolecular BiologyGenomicsHigh Throughput Sequencing +14

Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay

Alexandre Melnikov, Anand Murugan, Xiaolan Zhang, +10

Nature Biotechnology

Parallel ReporterSystems BiologyReporter Gene AssaySystematic DissectionStem Cell Research +7

Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits

Jacob C. Ulirsch, Satish K. Nandakumar, Li Wang, +8

Cell

BiologyGenetic AnalysisAllelic VariantPhenotypic VariationHaplotype Determination +7

Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay

Pouya Kheradpour, Jason Ernst, Alexandre Melnikov, +6

Genome Research

Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax

Daniel Hupalo, Zunping Luo, Alexandre Melnikov, +32

Nature Genetics

Disease ResistanceMolecular EcologyMedicineGeneticsMalaria +11

Comprehensive mutational scanning of a kinase <i>in vivo</i> reveals substrate-dependent fitness landscapes

Alexandre Melnikov, Peter Rogov, Li Wang, +2

Nucleic Acids Research

Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts

Liang Ma, Zehua Chen, Da Wei Huang, +41

Nature Communications

Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts

Joshua Z. Levin, Michael F. Berger, Xian Adiconis, +6

Genome biology

EngineeringMolecular BiologyTranscriptomics TechnologyHigh InterestCancer Transcriptome +19

Systematic dissection of genomic features determining transcription factor binding and enhancer function

Sharon R. Grossman, Xiaolan Zhang, Li Wang, +9

Proceedings of the National Academy of Sciences

GeneticsGene Regulatory NetworkGenomicsGene RecognitionGenomic Features +21