Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients

Cristina Bergamaschi, Evangelos Terpos, Margherita Rosati, +12

Cell Reports

Effect of Plasmid DNA Vaccine Design and In Vivo Electroporation on the Resulting Vaccine-Specific Immune Responses in Rhesus Macaques

Amara Luckay, Maninder K. Sidhu, Rune Kjeken, +14

Journal of Virology

ImmunologyHuman Immunodeficiency VirusImmunotherapyVivo ElectroporationRhesus Macaques +15

Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum

Cristina Bergamaschi, Jenifer Bear, Margherita Rosati, +7

Blood

Intracellular Interaction of Interleukin-15 with Its Receptor α during Production Leads to Mutual Stabilization and Increased Bioactivity

Cristina Bergamaschi, Margherita Rosati, Rashmi Jalah, +7

Journal of Biological Chemistry

ImmunologyImmune RegulationMutual StabilizationProduced Il-15Immunologic Mechanism +20

Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy

Antonio Valentin, Margherita Rosati, Daniel J. Patenaude, +6

Proceedings of the National Academy of Sciences

Dual effect of interleukin 4 on HIV-1 expression: Implications for viral phenotypic switch and disease progression

Antonio Valentin, Wenhong Lu, Margherita Rosati, +4

Proceedings of the National Academy of Sciences

ImmunologyHiv-1 IsolatesCcr5 ExpressionImmunotherapyInflammation +16

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

Beatriz Mothe, Xintao Hu, Anuska Llano, +18

Journal of Translational Medicine

Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation

Margherita Rosati, Antonio Valentin, Rashmi Jalah, +14

Vaccine

VaccinationMucosal VaccinationDna VaccinationVaccine DevelopmentRhesus Macaques +6

Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV89.6P challenge in rhesus macaques

Siew-Yen Chong, Michael A. Egan, Michele A. Kutzler, +14

Vaccine

Comparative AbilityVaccine DevelopmentShiv89.6p ChallengeRhesus MacaquesImmunology +7

DNA Vaccines Expressing Different Forms of Simian Immunodeficiency Virus Antigens Decrease Viremia upon SIVmac251 Challenge

Margherita Rosati, Agneta von Gegerfelt, Patricia Roth, +8

Journal of Virology