Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

Shannon Rose, Stepan Melnyk, Oleksandra Pavliv, +4

Translational Psychiatry

Autism BrainStressLipid PeroxidationPhysiologyOxidative Damage +12

Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism

Stepan Melnyk, George J. Fuchs, Eldon G. Schulz, +9

Journal of Autism and Developmental Disorders

Metabolic SyndromeNutritionMetabolic Imbalance AssociatedMetabolic DisorderSyndromic Autism +8

Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism

S. Jill James, Stepan Melnyk, George J. Fuchs, +5

American Journal of Clinical Nutrition

NutritionSyndromic AutismMedicinePediatricsNutritional Neuroscience +6

Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism

S. Jill James, Shannon Rose, Stepan Melnyk, +4

The FASEB Journal

Lipid PeroxidationImmunologyGlutathione Reserve CapacityLymphoblastoid CellsRedox Biology +16

Oxidative Stress Induces Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines in a Well-Matched Case Control Cohort

Shannon Rose, Richard E. Frye, John M. Slattery, +5

PLoS ONE

InflammationAutoimmune DiseaseMitochondrial FunctionBiochemistryMitochondrial Dysfunction +10

A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism

S. Jill James, Stepan Melnyk, Stefanie Jernigan, +6

American Journal of Medical Genetics Part B Neuropsychiatric Genetics

GeneticsEducationFolate PathwayEpigeneticsReduced Folate Carrier +14

Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability

Anna Shestakova, Elena S. Suvorova, Oleksandra Pavliv, +2

The Journal of Cell Biology

Molecular BiologyYeast CellsCellular PhysiologyT-snare Syntaxin5a/sed5Multi-protein Assembly +15

Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum

S. Jill James, Svitlana Shpyleva, Stepan Melnyk, +2

Translational Psychiatry

Histone ModificationsEpigenetic ChangeGeneticsMolecular BiologyComplex Epigenetic Regulation +20

Overexpression of LINE-1 Retrotransposons in Autism Brain

Svitlana Shpyleva, Stepan Melnyk, Oleksandra Pavliv, +2

Molecular Neurobiology

Molecular NeuroscienceAutism BrainDevelopmental Cognitive NeuroscienceSyndromic AutismGenetics +6

Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism

Shannon Rose, Stepan Melnyk, Timothy A. Trusty, +5

Autism Research and Treatment

Primary Immune CellsLipid PeroxidationImmunologyRedox BiologyOxidative Stress +15