Noel Timple

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90

Karen Lundgren, Hong Zhang, John Brekken et al. · Molecular Cancer Therapeutics · 2009 · 170 citations · Full text

Medicine, Oncology, Pharmacology +12

BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance

Hong Zhang, Laura Neely, Karen Lundgren et al. · International Journal of Cancer · 2009 · 72 citations

Medicine, Oncology, Pharmacology +14

Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations

John Tyhonas, Lee D. Arnold, Jason M. Cox et al. · Journal of Medicinal Chemistry · 2024 · 17 citations · Full text

Medicine, Molecular Medicine, Oncology +16

The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition

Young K. Chen, Toufike Kanouni, Lee D. Arnold et al. · Journal of Medicinal Chemistry · 2024 · 13 citations · Full text

Medicine, Oncology, Pharmacology +13

Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)

Lin Zhang, Junhua Fan, Jer-Hong Chong et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 10 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11