7‘-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors

Lin Zhang, Junhua Fan, K. NGUYEN VU, +17

Journal of Medicinal Chemistry

Pyridino- ThiazolothiopurinesPharmaceutical ScienceDrug TargetPharmacotherapyChemical Biology +16

Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90

Marco A. Biamonte, Jiandong Shi, Kevin Hong, +15

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceBiochemistryHsp90 InhibitorsMedicine +10

Identification of new biomarkers for clinical trials of Hsp90 inhibitors

Hong Zhang, Daun Chung, Yong‐Ching Yang, +8

Molecular Cancer Therapeutics

ImmunologyPathologyNew BiomarkersPharmacotherapyBiomarker (Medicine) +18

Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1

Jean‐Yves Le Brazidec, Angela Pasis, Betty Y. Tam, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDual InhibitorsNatural SciencesMedicineBiological Evaluation +7

Silencing cathepsin S gene expression inhibits growth, invasion and angiogenesis of human hepatocellular carcinoma in vitro

Qi Fan, Xuedi Wang, Hanguang Zhang, +3

Biochemical and Biophysical Research Communications

HepatologyHuman Hepatocellular CarcinomaLiver PhysiologyImmunologyPathology +7

Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors

Jean‐Yves Le Brazidec, Angela Pasis, Betty Y. Tam, +16

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryMedicineStructure-based DesignPharmacology +1

Structure-based design of low-nanomolar PIM kinase inhibitors

Alexey Ishchenko, Lin Zhang, Jean‐Yves Le Brazidec, +11

Bioorganic & Medicinal Chemistry Letters

EngineeringMedicineDrug DiscoveryPharmacologyRational Drug Design +4

Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells

Misako Harato, Lei Huang, Fumio Kondo, +6

BMC Neuroscience

Naofen promotes TNF-α-mediated apoptosis of hepatocytes by activating caspase-3 in lipopolysaccharide-treated rats

Junhua Fan

World Journal of Gastroenterology

Dimeric ansamycins—A new class of antitumor Hsp90 modulators with prolonged inhibitory activity

Hong Zhang, Yong‐Ching Yang, Lin Zhang, +8

International Journal of Cancer

Drug TargetApoptosisCell DeathPharmacotherapyTumor Biology +16