Jean‐Yves Le Brazidec

7‘-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors

Lin Zhang, Junhua Fan, K. NGUYEN VU et al. · Journal of Medicinal Chemistry · 2006 · 114 citations · Full text

Pyridino- Thiazolothiopurines, Pharmaceutical Science, Drug Target +18

Synthesis and Biological Evaluation of a New Class of Geldanamycin Derivatives as Potent Inhibitors of Hsp90

Jean‐Yves Le Brazidec, Adeela Kamal, David J. Busch et al. · Journal of Medicinal Chemistry · 2004 · 84 citations · Full text

Pharmaceutical Science, Chemical Biology, Pharmaceutical Chemistry +17

Practical entry into the HIJKLM ring segment of ciguatoxin CTX3C

Tohru Oishi, Hisatoshi Uehara, Yoko Nagumo et al. · Chemical Communications · 2001 · 42 citations

Biology, Heterocyclic, Natural Sciences +12

Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1

Jean‐Yves Le Brazidec, Angela Pasis, Betty Y. Tam et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 39 citations · Full text

Medicinal Chemistry, Dual Inhibitors, Natural Sciences +9

Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors

Jean‐Yves Le Brazidec, Angela Pasis, Betty Y. Tam et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 27 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Medicine +3