Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition

Wanfeng Xu, Yuan Che, Quan Zhang, +6

Cell Metabolism

BiochemistryMitochondrial FunctionNatural SciencesMitochondrial DynamicMolecular Biology +3

Qingchang Huashi Formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function

Jingyi Hu, Hai Huang, Yuan Che, +6

Journal of Ethnopharmacology

InflammationGut Microbiota-metabolism HomeostasisDysbiosisPathogenesisImmunology +9

Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming

Qingran Li, Lijuan Cao, Yang Tian, +9

Molecular & Cellular Proteomics

Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner

Qingran Li, Chujie Ding, Tuo Meng, +4

Journal of Pharmacological Sciences

Hdac InhibitorChemoprevention StrategyMedicinePharmacologyColorectal Cancer +11

Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions

Yuan Che, Wanfeng Xu, Chujie Ding, +10

Cell Reports

Lipid PeroxidationInnate Immune SystemImmunologyCell DeathInnate Immunity +17

Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure

Wanfeng Xu, Quan Zhang, Chujie Ding, +7

Acta Pharmacologica Sinica

InflammationHepatologyMedicineLiver PhysiologyImmunology +9

Ginsenosides regulation of lysophosphatidylcholine profiles underlies the mechanism of Shengmai Yin in attenuating atherosclerosis

Yun Wang, Jiawei Wu, Jia‐Ying Zhu, +6

Journal of Ethnopharmacology

Bile acid restrained T cell activation explains cholestasis aggravated hepatitis B virus infection

Chujie Ding, Yu Hong, Yuan Che, +8

The FASEB Journal

Polyunsaturated fatty acids drive neutrophil extracellular trap formation in nonalcoholic steatohepatitis

Jiawei Wu, Chuan Zhang, Tianyu He, +8

European Journal of Pharmacology

InflammationMetabolic Associated SteatohepatitisHepatologyMetabolic Associated Steatotic Liver DiseaseNonalcoholic Fatty Liver Disease +11

Ginsenosides retard atherogenesis via remodelling host–microbiome metabolic homeostasis

Yun Wang, Jiawei Wu, Yu Hong, +9

British Journal of Pharmacology