Tiffany J. Choy

Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

Christopher J. Schulze, Kyle J. Seamon, Yulei Zhao et al. · Science · 2023 · 232 citations · Full text

Medicine, Medicinal Chemistry, Oncology +17

Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment

Elsa Quintana, Christopher J. Schulze, Darienne R. Myers et al. · Cancer Research · 2020 · 97 citations

Medicine, Immunology, Oncology +17

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity

Darienne R. Myers, Clare L. Abram, David Wildes et al. · Frontiers in Immunology · 2020 · 47 citations · Full text

Life Sciences, Immunology, Oncology +17

Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation

Qi Ye, Ju-Yeon Jo, Chih‐Yen Wang et al. · Cell Reports · 2024 · 40 citations · Full text

Medicine, Neurobiology, Neuroscience +17

A06 Tri-complex Inhibitors of the Oncogenic, GTP-Bound Form of KRASG12C Overcome RTK-Mediated Escape Mechanisms and Drive Tumor Regressions in Preclinical Models of NSCLC

R. Jeremy Nichols, Chris J. Schulze, Alun Bermingham et al. · Journal of Thoracic Oncology · 2020 · 23 citations · Full text

Medicine, Medicinal Chemistry, Oncology +16