IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Satoshi Kofuji, Akiyoshi Hirayama, Alexander Otto Eberhardt, +54

Nature Cell Biology

Neuro-oncologyGliomaOncogenic AgentMedicineTumor Suppressor +5

The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death

Junko Sasaki, Satoshi Kofuji, Reietsu Itoh, +17

Nature

Excitotoxic Neuronal DeathMolecular NeuroscienceSignal TransductionP2 Phosphatase Inpp4aMedicine +10

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis

Kazutaka Sumita, Yu-Hua Lo, Koh Takeuchi, +18

Molecular Cell

Signal TransductionSignaling PathwayBiochemistryMedicineNatural Sciences +9

INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor

Satoshi Kofuji, Hirotaka Kimura, Hiroki Nakanishi, +15

Cancer Discovery

PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma

Hirofumi Yoshino, Nijiro Nohata, Kazutaka Miyamoto, +8

Cancer Research

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

Seong Min Kim, Saurabh G. Roy, Bin Chen, +21

Journal of Clinical Investigation

Chemoprevention StrategyMetabolic RemodelingCancer BiologyTumor BiologyOncogenic Mutations +23

microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma

Hirofumi Yoshino, Masaya Yonemori, Kazutaka Miyamoto, +5

Oncotarget

Crispr/cas9 GeneTumor BiologyGenitourinary CancerCancer Cell BiologyRenal Cell Carcinoma +14

Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine

Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, +19

Proceedings of the National Academy of Sciences

In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells

Daewoo Han, Mika Sasaki, Hirofumi Yoshino, +3

Journal of Drug Delivery Science and Technology

Tissue EngineeringNeuro-oncologyCell-based Drug DeliveryMembrane FormationEngineering +9

Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

Laura Ren Huey Ip, George Poulogiannis, Felipe Cia Viciano, +7

Oncotarget