Adam Pavlı́c̀ek

The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

Jill Hallin, Lars D. Engstrom, Lauren Hargis et al. · Cancer Discovery · 2019 · 1.2K citations · Full text

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

Jill Hallin, Vickie Bowcut, Andrew Calinisan et al. · Nature Medicine · 2022 · 465 citations

Medicine, Pharmacology, Pharmacotherapy +7

Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial

Meike H. van der Ree, J. Marleen de Vree, F. Stelma et al. · The Lancet · 2017 · 259 citations

Phase 1B, Hepatology, Hepatitis C +7

The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein

Natalay Kouprina, Adam Pavlı́c̀ek, N. Keith Collins et al. · Human Molecular Genetics · 2005 · 205 citations

Brain Development, Cell Death, Mitotic Spindle Protein +19

Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion

Natalay Kouprina, Adam Pavlı́c̀ek, Ganeshwaran H. Mochida et al. · PLoS Biology · 2004 · 197 citations · Full text

Brain Development, Genetics, Genomic Mechanism +21