Leo Beigelman

Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study

John P. DeVincenzo, Matthew W. McClure, Julian Symons et al. · New England Journal of Medicine · 2015 · 229 citations · Full text

Pharmacy, Infectious Diseases, Pharmacotherapy +15

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-<i>O</i>-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Guangyi Wang, Jérôme Deval, Jin Tae Hong et al. · Journal of Medicinal Chemistry · 2015 · 138 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase

Paul C. Jordan, Cheng Liu, Pauline Raynaud et al. · PLoS Pathogens · 2018 · 138 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Jérôme Deval, Jin Tae Hong, Guangyi Wang et al. · PLoS Pathogens · 2015 · 95 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases.

Alessio Peracchi, Leo Beigelman, Nassim Usman et al. · Proceedings of the National Academy of Sciences · 1996 · 91 citations

Life Sciences, Evolutionary Biology, Molecular Biology +13