Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

Bradley N. Bidwell, Clare Y. Slaney, Nimali P. Withana, +15

Nature Medicine

Breast OncologySignaling PathwayMedicineIrf7 PathwaysImmunology +6

Improved Quenched Fluorescent Probe for Imaging of Cysteine Cathepsin Activity

Martijn Verdoes, Kristina Oresic Bender, Ehud Segal, +5

Journal of the American Chemical Society

Tumor ImagingSingle Molecule BiophysicsEngineeringBiochemistryNatural Sciences +12

Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer

Nimali P. Withana, Galia Blum, Mansoureh Sameni, +11

Cancer Research

Functional Imaging of Legumain in Cancer Using a New Quenched Activity-Based Probe

Laura E. Edgington‐Mitchell, Martijn Verdoes, Alberto Ortega, +6

Journal of the American Chemical Society

EngineeringOncologic ImagingPrimary MacrophagesImmunologyCancer Biology +17

Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

Leslie O. Ofori, Nimali P. Withana, Tyler R. Prestwood, +5

ACS Chemical Biology

EngineeringBiomedical EngineeringOptogeneticsCathepsin-targeted Substrate ProbesBiomedical Optic +14

Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes

Nimali P. Withana, Xiaowei Ma, Helen M. McGuire, +18

Scientific Reports

Detection of Intestinal Cancer by Local, Topical Application of a Quenched Fluorescence Probe for Cysteine Cathepsins

Ehud Segal, Tyler R. Prestwood, Wouter A. van der Linden, +7

Chemistry & Biology

Immunocytochemical TechniqueBiochemistryCancer DetectionBioanalysisHistopathology +8

Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation

Nimali P. Withana, Toshinobu Saito, Xiaowei Ma, +11

Journal of Nuclear Medicine

Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes

Nimali P. Withana, Megan Garland, Martijn Verdoes, +3

Nature Protocols

Immunocytochemical TechniqueBiochemistryMedicineNatural SciencesBioanalysis +10

Abstract CT049: Phase Ib study evaluating a triplet combination of ipatasertib (IPAT), atezolizumab (atezo), and paclitaxel (PAC) or nab-PAC as first-line (1L) therapy for locally advanced/metastatic triple-negative breast cancer (TNBC)

Peter Schmid, Delphine Loirat, Peter Savas, +11

Cancer Research

Breast OncologyImmunologyImmunoeditingImmunotherapeuticsImmunotherapy +19