Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

Leslie O. Ofori, Nimali P. Withana, Tyler R. Prestwood, +5

ACS Chemical Biology

EngineeringBiomedical EngineeringOptogeneticsCathepsin-targeted Substrate ProbesBiomedical Optic +14

Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes

Nimali P. Withana, Xiaowei Ma, Helen M. McGuire, +18

Scientific Reports

From dynamic combinatorial ‘hit’ to lead: in vitro and in vivo activity of compounds targeting the pathogenic RNAs that cause myotonic dystrophy

Leslie O. Ofori, Jason W. Hoskins, Masayuki Nakamori, +2

Nucleic Acids Research

Medicinal ChemistryDrug TargetMyotonic DystrophiesBiochemistryToxic Rna +13

Design of a Highly Selective Quenched Activity-Based Probe and Its Application in Dual Color Imaging Studies of Cathepsin S Activity Localization

Kristina Oresic Bender, Leslie O. Ofori, Wouter A. van der Linden, +10

Journal of the American Chemical Society

Immunocytochemical TechniqueImmunologyIndividual CathepsinsChemical BiologyImmunotherapy +19

Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion

Matthew A. Child, Carolyn I. Hall, Josh R. Beck, +9

Nature Chemical Biology

Signal TransductionNatural SciencesCell InteractionSmall-molecule InhibitionCellular Biochemistry +4

Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation

Nimali P. Withana, Toshinobu Saito, Xiaowei Ma, +11

Journal of Nuclear Medicine

Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes

Nimali P. Withana, Megan Garland, Martijn Verdoes, +3

Nature Protocols

Immunocytochemical TechniqueBiochemistryMedicineNatural SciencesBioanalysis +10

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

Jason W. Hoskins, Leslie O. Ofori, Catherine Z. Chen, +11

Nucleic Acids Research

High-Affinity Recognition of HIV-1 Frameshift-Stimulating RNA Alters Frameshifting in Vitro and Interferes with HIV-1 Infectivity

Leslie O. Ofori, Thomas A. Hilimire, Ryan P. Bennett, +3

Journal of Medicinal Chemistry

Viral ReplicationImmunologyMolecular BiologyAntiviral DrugHuman Retrovirus +14

Strategies for Recognition of Stem−Loop RNA Structures by Synthetic Ligands: Application to the HIV-1 Frameshift Stimulatory Sequence

Prakash B. Palde, Leslie O. Ofori, Peter C. Gareiss, +2

Journal of Medicinal Chemistry