In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy

Paul Tardi, Sharon A. Johnstone, Natashia Harasym, +6

Leukemia Research

Daunorubicin RatiosPharmacologyVivo MaintenancePharmacotherapyDrug Development +5

Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice

Lawrence D. Mayer, Troy O. Harasym, Paul Tardi, +6

Molecular Cancer Therapeutics

Coencapsulation of irinotecan and floxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo

Paul Tardi, Ryan Gallagher, Sharon A. Johnstone, +4

Biochimica et Biophysica Acta (BBA) - Biomembranes

Lipid PreparationOxysterolLow Cholesterol-containing LiposomesMedicineDrug Release +4

Modulating the Therapeutic Activity of Nanoparticle Delivered Paclitaxel by Manipulating the Hydrophobicity of Prodrug Conjugates

Steven M. Ansell, Sharon A. Johnstone, Paul Tardi, +11

Journal of Medicinal Chemistry

Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles

Igor V. Zhigaltsev, Geoff Winters, Masuna Srinivasulu, +6

Journal of Controlled Release

NanomedicineMedicinal ChemistryEngineeringWeak-base Docetaxel DerivativeLipid Nanoparticles +4

Increased Preclinical Efficacy of Irinotecan and Floxuridine Coencapsulated Inside Liposomes Is Associated With Tumor Delivery of Synergistic Drug Ratios

Troy O. Harasym, Paul Tardi, Natashia Harasym, +3

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

NanotherapeuticsPharmacotherapyTumor BiologyOncologyPreclinical Efficacy +17

Liposomal Irinotecan

Corrie Lynn Messerer, Euan C. Ramsay, Dawn Waterhouse, +6

Clinical Cancer Research

In vitro and in vivo characterization of a combination chemotherapy formulation consisting of vinorelbine and phosphatidylserine

Murray S. Webb, Sharon A. Johnstone, Tara Morris, +9

European Journal of Pharmaceutics and Biopharmaceutics

Pharmaceutical ScienceCombination Chemotherapy FormulationMedicineDrug DiscoveryPharmacotherapy +7

Treatment of Colorectal Cancer Using a Combination of Liposomal Irinotecan (Irinophore C™) and 5-Fluorouracil

Jennifer I. Hare, Robert W. Neijzen, Malathi Anantha, +6

PLoS ONE

Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities

Dawn Waterhouse, Brent W. Sutherland, Nancy Dos Santos, +10

Investigational New Drugs