Liye Chen

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

Grazyna Kochan, T. Krojer, David Harvey et al. · Proceedings of the National Academy of Sciences · 2011 · 256 citations · Full text

A genetics-led approach defines the drug target landscape of 30 immune-related traits

Hai Fang, Hans Wolf, Bogdan Knezevic et al. · Nature Genetics · 2019 · 221 citations · Full text

Drug Target Landscape, Immunogenetics, Genetics-led Approach +12

A biallelic mutation in <i>IL6ST</i> encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

Tobias Schwerd, Stephen R.F. Twigg, Dominik Aschenbrenner et al. · The Journal of Experimental Medicine · 2017 · 193 citations · Full text

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis

Liye Chen, Anna Ridley, Ariane Hammitzsch et al. · Annals of the Rheumatic Diseases · 2015 · 84 citations · Full text

Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA–B27

Liye Chen, Román Fischer, Yanchun Peng et al. · Arthritis & Rheumatology · 2013 · 73 citations