Graham P. Luscombe

The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation

W. R. Buckett, P. C. Thomas, Graham P. Luscombe · Progress in Neuro-Psychopharmacology and Biological Psychiatry · 1988 · 149 citations

Medicine, Pharmacology, Pharmacotherapy +17

The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochloride

Graham P. Luscombe, Rebecca Hopcroft, P C Thomas et al. · Neuropharmacology · 1989 · 95 citations

Medicine, Neuroscience, Pharmacology +10

Mediation of the antidepressant‐like effect of 8‐OH‐DPAT in mice by postsynaptic 5‐HT_1A receptors

Graham P. Luscombe, Keith F. Martin, Lisa J. Hutchins et al. · British Journal of Pharmacology · 1993 · 87 citations · Full text

Medicine, Pharmacology, Psychiatry +17

A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramine

David J. Heal, A. T. J. Frankland, Jane Gosden et al. · Psychopharmacology · 1992 · 63 citations

Medicine, Neuroscience, Pharmacology +16

Effect on radiolabelled-monoamine uptake in vitro of plasma taken from healthy volunteers administered the antidepressant sibutramine HCl

Graham P. Luscombe, Nigel A. Slater, Michael B. Lyons et al. · Psychopharmacology · 1990 · 45 citations

Medicine, Pharmacokinetics, Pharmacology +11