Graham P. Luscombe - Concepedia

Author

Graham P. Luscombe

Vertex Pharmaceuticals (United Kingdom)

Also Known As

G Luscombe, G. Luscombe, G. P. Luscombe, G.P. Luscombe, Graham Luscombe, Graham P. Luscombe

Publications

645

Citations

H-Index

Concepts

All Affiliations

Vertex Pharmaceuticals (United Kingdom)King's College Hospital Walgreens Boots Alliance (United Kingdom)

About

Graham P. Luscombe is an author at Vertex Pharmaceuticals (United Kingdom) specializing in medicine, neuropharmacology, and pharmacology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	12	13	599
2	Health Sciences	4	4	102
3	Social Sciences	4	4	261
4	Anesthesia	1	1	21
5	Endocrinology	1	1	95

Graham P. Luscombe

Publications

611

Citations

H-Index

Page 1

	Year	Citations
The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation W. R. Buckett, P. C. Thomas, Graham P. Luscombe Progress in Neuro-Psychopharmacology and Biological Psychiatry Psychoactive DrugSibutramine HydrochloridePsychiatryMedicineRapid Noradrenergic Down-regulation	1988	148
The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochloride Graham P. Luscombe, Rebecca Hopcroft, P C Thomas, Neuropharmacology Stress HormonePsychiatryMedicineNeuroendocrine MechanismRat Cortical β-Adrenoceptors	1989	95
Mediation of the antidepressant‐like effect of 8‐OH‐DPAT in mice by postsynaptic 5‐HT<sub>1A</sub> receptors Graham P. Luscombe, Keith F. Martin, Lisa J. Hutchins, British Journal of Pharmacology PsychopharmacologyPharmacotherapyExperimental PharmacologySocial SciencesMolecular Pharmacology	1993	86
A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramine David J. Heal, A. T. J. Frankland, Jane Gosden, Psychopharmacology Psychoactive DrugSibutramine HydrochlorideAddictionMedicineNeuropharmacology	1992	63
Effect on radiolabelled-monoamine uptake in vitro of plasma taken from healthy volunteers administered the antidepressant sibutramine HCl Graham P. Luscombe, Nigel A. Slater, Michael B. Lyons, Psychopharmacology Psychoactive DrugRadiolabelled-monoamine UptakePsychiatryMedicineHealthy Volunteers	1990	45
Pharmacological analysis of the myoclonus induced by 5-hydroxytryptophan in the guinea pig suggests the presence of multiple 5-hydroxytryptamine receptors in the brain Graham P. Luscombe, Peter Jenner, C. D. Marsden Neuropharmacology NeurophysiologyNeuroanatomyMedicinePhysiologyNeuropharmacology	1981	29
5-Hydroxytryptamine (5-HT)-dependent myoclonus in guinea pigs is induced through brainstem 5-HT-1 receptors Graham P. Luscombe, Peter Jenner, C. D. Marsden Neuroscience Letters Guinea PigsNeurophysiologyMedicinePhysiologyNeuroendocrine Mechanism	1984	28
Tryptamine-induced myoclonus in guinea-pigs pretreated with a monoamine oxidase inhibitor indicates pre- and post-synaptic actions of tryptamine upon central indoleamine systems Graham P. Luscombe, Peter Jenner, C. D. Marsden Neuropharmacology Psychoactive DrugNeurophysiologyNeuroanatomyMedicinePhysiology	1982	24
Myoclonus in guinea pigs is induced by indole-containing but not piperazine-containing 5HT agonists Graham P. Luscombe, Peter Jenner, C. D. Marsden Life Sciences Molecular PharmacologyPiperazine-containing 5HtHealth SciencesGuinea PigsPharmacological Study	1982	21
Comparative pharmacology of dothiepin, its metabolites, and other antidepressant drugs David J. Heal, Sharon C. Cheetham, Keith F. Martin, Drug Development Research Comparative PharmacologyPsychotropic MedicationNorthiaden SulfoxidePsychopharmacologySulfoxide Metabolites	1992	19

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