The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochloride

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt Rd, Aurélie Bertin, M Jalfre · PubMed · 1977 · 3.3K citations

Medicine, Pharmacology, Psychiatry +17

Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethyl-meta-tyramine

Arvid Carlsson, H. Corrodi, Kjell Fuxé et al. · European Journal of Pharmacology · 1969 · 648 citations

Medicine, Neuroscience, Pharmacology +14

REGIONAL DIFFERENCES IN H3-NOREPINEPHRINE AND H3-DOPAMINE UPTAKE INTO RAT BRAIN HOMOGENATES

Solomon H. Snyder, Joseph T. Coyle · Journal of Pharmacology and Experimental Therapeutics · 1969 · 431 citations

Life Sciences, Neurobiology, Neuroscience +10

Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,α-dimethyl-meta-tyramine

Arvid Carlsson, H. Corrodi, Kjell Fuxé et al. · European Journal of Pharmacology · 1969 · 415 citations

Medicine, Neuroscience, Pharmacology +14

Behavioural despair in mice : A primary screening test for antidepressants

R. D. Porsalt · Medical Entomology and Zoology · 1977 · 332 citations

Medicine, Pharmacology, Psychiatry +14