Interplay between metabolic identities in the intestinal crypt supports stem cell function

Maria J. Rodríguez Colman, Matthias Schewe, Maaike Meerlo, +10

Nature

Developmental BiologyMedicineAdult Stem CellIntestinal Crypt SupportsGut-organ Axis +8

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

Mark R. Schmitt, Matthias Schewe, Andrea Sacchetti, +10

Cell Reports

Human TROP-2 is a tumor-associated calcium signal transducer

Elisabetta Rapani, Andrea Sacchetti, Daniela Corda, +1

International Journal of Cancer

Paneth Cells in Intestinal Homeostasis and Tissue Injury

Sabrina Roth, Patrick Franken, Andrea Sacchetti, +4

PLoS ONE

Regenerative MedicineCell LineageDevelopmental BiologyMedicinePaneth Cells +10

IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo

Linda B.C. Bralten, Nanne K. Kloosterhof, Rutger K. Balvers, +16

Annals of Neurology

Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer

Matthias Schewe, Patrick Franken, Andrea Sacchetti, +12

Cell stem cell

InflammationSignal TransductionSignaling PathwayReceptor Tyrosine KinaseImmunology +7

De Novo Synthesis of Cyclooxygenase-1 Counteracts the Suppression of Platelet Thromboxane Biosynthesis by Aspirin

Virgilio Evangelista, Stefano Manarini, Angelo Di Santo, +9

Circulation Research

EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways

Sandra Donnini, Federica Finetti, Raffaella Solito, +5

The FASEB Journal

Pge2 EffectsChemoprevention StrategyImmunologyPathologyErk1/2 Pathways +16

IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden

Marten van der Zee, Andrea Sacchetti, Medine Cansoy, +7

Cancer Research

GynecologyCancer Stem-like CellsTumor BiologySignaling PathwayStem Cells +16

Wnt Signaling Regulates the Lineage Differentiation Potential of Mouse Embryonic Stem Cells through Tcf3 Down-Regulation

Yaser Atlasi, Rubina Noori, Cláudia Gaspar, +8

PLoS Genetics

Wnt SignalingStem Cell BiologyCell SpecializationSignaling PathwayCell Regulation +16