Ingeborg M. Nieuwenhuizen

The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo

Edwin Mientjes, Ingeborg M. Nieuwenhuizen, Laura Kirkpatrick et al. · Neurobiology of Disease · 2005 · 286 citations · Full text

Knockout Mouse, Signal Transduction, Conditional Fmr1 Knock +6

Elevated Fmr1 mRNA levels and reduced protein expression in a mouse model with an unmethylated Fragile X full mutation

Judith R. Brouwer, Edwin Mientjes, C.E. Bakker et al. · Experimental Cell Research · 2006 · 130 citations · Full text

Knockout Mouse, Genome Instability, Protein Expression +13

AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

Josien Levenga, Shigemi Hayashi, Femke M.S. de Vrij et al. · Neurobiology of Disease · 2011 · 120 citations · Full text

Fragile X Syndrome, Medicine, New Mglur5 Antagonist +6

Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant

Andreea Pop, Josien Levenga, Celine de Esch et al. · Psychopharmacology · 2012 · 85 citations

Inflammation, Dendritic Spine Phenotype, Fmr1 Ko Mice +6

Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice

Josien Levenga, Femke M.S. de Vrij, Ronald A.M. Buijsen et al. · Neurobiology of Learning and Memory · 2011 · 50 citations

Synaptic Plasticity, Fmr1 Ko Mice, Brain Structure +7