Jimmy Lu

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability

Bing Bai, Alexandr Belovodskiy, Mostofa Abu Hena et al. · Journal of Medicinal Chemistry · 2021 · 107 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors

Bing Bai, Elena Arutyunova, Muhammad Bashir Khan et al. · RSC Medicinal Chemistry · 2021 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

SARS-CoV-2 M^pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu et al. · ACS Central Science · 2023 · 60 citations · Full text

Life Sciences, Biochemistry, Infectious Diseases +17

N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer

Elena Arutyunova, Muhammad Bashir Khan, Conrad Fischer et al. · Journal of Molecular Biology · 2021 · 47 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +4

Crystallization of Feline Coronavirus Mpro With GC376 Reveals Mechanism of Inhibition

Jimmy Lu, Sizhu Amelia Chen, Muhammad Bashir Khan et al. · Frontiers in Chemistry · 2022 · 44 citations · Full text

Life Sciences, Infectious Diseases, Medicinal Chemistry +17