Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, +11

Nature Communications

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability

Bing Bai, Alexandr Belovodskiy, Mostofa Abu Hena, +22

Journal of Medicinal Chemistry

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, +11

Viral ReplicationM ProMedicineViral PathogenesisImmunology +13

The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides

Shaun M. K. McKinnie, Conrad Fischer, Kelvin M. H. Tran, +4

ChemBioChem

Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury

Andrew G Masoud, Jiaxin Lin, Abul Kalam Azad, +13

Journal of Clinical Investigation

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs

Wang Wang, Mengcheng Shen, Conrad Fischer, +14

Proceedings of the National Academy of Sciences

Fine tuning of crystal architecture by intermolecular interactions: synthon engineering

Petra Bombicz, Tobias Gruber, Conrad Fischer, +2

CrystEngComm

Supramolecular AssemblyEngineeringDirected ManipulationMolecular BiologySynthetic Circuit +16

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents

Conrad Fischer, Tess Lamer, Wang Wang, +5

European Journal of Medicinal Chemistry

HypertensionBiochemistryMedicineAntihypertensive TherapyVascular Biology +5

N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer

Elena Arutyunova, Muhammad Bashir Khan, Conrad Fischer, +9

Journal of Molecular Biology

Sars-cov-2 Mpro DimerMedicineMolecular BiologyN-terminal Finger StabilizesS1 Pocket +2

Synthetic Modification within the “RPRL” Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation

Shaun M. K. McKinnie, Wang Wang, Conrad Fischer, +6

Journal of Medicinal Chemistry

Peptide SciencePlasma DegradationMolecular PharmacologyMedicinal ChemistryProtein Degradation +17