Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, +11

Nature Communications

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors

Aravindhan Ganesan, Marawan Ahmed, Isobel Okoye, +26

Scientific Reports

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability

Bing Bai, Alexandr Belovodskiy, Mostofa Abu Hena, +22

Journal of Medicinal Chemistry

Oxidation of glyceraldehyde-3-phosphate dehydrogenase enhances its binding to nucleic acids

Elena Arutyunova, Pauline V Danshina, Lydia V Domnina, +2

Biochemical and Biophysical Research Communications

Nucleic Acid ChemistryCellular EnzymologyBiochemistryNatural SciencesNucleic Acid Biochemistry +6

ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis Virus

Nadia V. Giannakopoulos, Elena Arutyunova, C J Lai, +3

Journal of Virology

Viral ReplicationIsg15 Arg151ImmunologySindbis VirusInnate Immunity +17

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, +11

Viral ReplicationM ProMedicineViral PathogenesisImmunology +13

Allosteric regulation of rhomboid intramembrane proteolysis

Elena Arutyunova, Pankaj Panwar, Pauline M Skiba, +3

The EMBO Journal

BiochemistryAllosteric RegulationNatural SciencesProtein TransportIntracellular Trafficking +1

Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors

Bing Bai, Elena Arutyunova, Muhammad Bashir Khan, +14

RSC Medicinal Chemistry

SARS-CoV-2 M^pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu, +16

ACS Central Science

N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer

Elena Arutyunova, Muhammad Bashir Khan, Conrad Fischer, +9

Journal of Molecular Biology

Sars-cov-2 Mpro DimerMedicineMolecular BiologyN-terminal Finger StabilizesS1 Pocket +2