Charlotte East

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2

Tom D. Heightman, Valério Berdini, Hannah Braithwaite et al. · Journal of Medicinal Chemistry · 2018 · 63 citations · Full text

Multiple Cancers, Tumor Biology, Medicinal Chemistry +22

ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK

Joanne M. Munck, Valério Berdini, Luke Bevan et al. · Molecular Cancer Therapeutics · 2021 · 32 citations · Full text

In-gel activity-based protein profiling of a clickable covalent ERK1/2 inhibitor

Honorine Lebraud, David J. Wright, Charlotte East et al. · Molecular BioSystems · 2016 · 22 citations

X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor

Jeffrey D. St. Denis, Gianni Chessari, Anne Cleasby et al. · Journal of Medicinal Chemistry · 2022 · 22 citations · Full text

Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2

Tom D. Heightman, Valério Berdini, Luke Bevan et al. · Journal of Medicinal Chemistry · 2021 · 17 citations · Full text