Nicholas Wightman

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Publications

Citations

473

H-Index

Active since

2010

Affiliations

University of Massachusetts Chan Medical School(Current)

Mayo Clinic in Florida

Nicholas Wightman is an author at University of Massachusetts Chan Medical School specializing in life sciences, gene expression, and molecular biology.

Publications per year

2010–2023

Publications

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

Owen M. Peters, Gabriela Toro Cabrera, Hélène Tran et al. · Neuron · 2015 · 257 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

Hélène Tran, Michael P. Moazami, Huiya Yang et al. · Nature Medicine · 2021 · 174 citations · Full text

Life Sciences, Genetics, Molecular Biology +12

BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model

Esteban Quezada, Claudio Cappelli, Iván Darío Parrado Díaz et al. · Clinical Epigenetics · 2021 · 17 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo

Gabriela Toro Cabrera, Katharina E. Meijboom, Abbas Abdallah et al. · Gene Therapy · 2023 · 13 citations

Life Sciences, Genetics, Molecular Biology +13

Screening for inhibitors of the SOD1 gene promoter: Pyrimethamine does not reduce SOD1 levels in cell and animal models

Paul D. Wright, Mickey Huang, Alexandra Weiss et al. · Neuroscience Letters · 2010 · 12 citations

Life Sciences, Molecular Biology, Pharmacology +11

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