Jane X. Liu

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

Christopher Blackburn, Kenneth M. Gigstad, Paul Hales et al. · Biochemical Journal · 2010 · 146 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +14

Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome

Christopher Blackburn, Cynthia Barrett, Jonathan L. Blank et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 40 citations

Life Sciences, Biochemistry, Molecular Biology +15

Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors

Christopher Blackburn, Matthew O. Duffey, Alexandra E. Gould et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors

Alexandra E. Gould, Ruth Adams, Sharmila Adhikari et al. · Journal of Medicinal Chemistry · 2011 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery and optimization of pyrazoline compounds as B-Raf inhibitors

Matthew O. Duffey, Ruth Adams, Christopher Blackburn et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 15 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14