Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN

Bin Liu, Shangwen Jiang, Min Li, +12

Nature Communications

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

Juan J. Miret, Paul T. Kirschmeier, Shohei Koyama, +13

Journal for ImmunoTherapy of Cancer

Characterization of the Immune Landscape of EGFR-Mutant NSCLC Identifies CD73/Adenosine Pathway as a Potential Therapeutic Target

Xiuning Le, Marcelo V. Negrão, Alexandre Reuben, +36

Journal of Thoracic Oncology

Potential Therapeutic TargetCancer ImmunosurveillanceImmunologyTumor ImmunityImmune Landscape +7

The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model

Litong Nie, Lin Shuai, Mingrui Zhu, +5

Molecular & Cellular Proteomics

Histone ModificationsMetabolic DisorderHistone MarksFatty Liver DiseaseEpigenetics +19

Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells

Hitoshi Shiota, Sophie Barral, Thierry Buchou, +19

Cell Reports

Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein

Shijie Fan, Liyan Yue, Wei Wan, +24

Angewandte Chemie International Edition

Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis

Mingrui Zhu, Yi Huang, Matthew E. Bender, +11

Cancer Research

Innate Immune SystemImmunologyNk CellsInnate ImmunityImmunotherapy +17

Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells

Jia Qu, Wenyi Sun, Jie Zhong, +10

The Journal of Cell Biology

Molecular BiologyRegulates Dntp PoolCancer BiologyTumor BiologyPgam1 Inhibitors +17

Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

Salim Abdisalaam, Souparno Bhattacharya, Shibani Mukherjee, +7

Journal of Biological Chemistry

Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden

Mingrui Zhu, Jiwoong Kim, Qing Deng, +14

Cancer Cell

Cancer ImmunosurveillanceTumor HeterogeneityMedicineImmunologyTumor Immunity +5